In 2023, a devastating earthquake struck Herat province, impacting an estimated 114,000 people, with 94,000 requiring urgent assistance. The disaster destroyed homes and critical infrastructure, severely limiting access to food, sanitation, and healthcare. Affected people reported feeling unsafe and lacked essential services like mental health support and protection. H-WHO provided critical health and nutrition services, psychosocial support, trauma care, and child protection interventions through 3 mobile health team supported by national and international traders. This response aimed at meeting immediate needs while preparing for winter by distributing shelters, warm clothing, blankets, and heating materials.​

On August 31, 2025, a 6.0 magnitude earthquake hit eastern Afghanistan, severely affecting Kunar province, especially Nurgal district. The event caused massive destruction, casualties, and further infrastructure damage amid intense flash flooding. The H-WHO responded promptly by mobilizing local resources through local volunteers supporting rescue and relief efforts and donating blood. Specialized rehabilitation and mental health teams prepared to provide physical rehab, mobility aids, psychological first aid, and support services for vulnerable groups including children and people with disabilities. The response including shelter, healthcare, food, and psychosocial support amplified by access challenges due to damaged roads and communication blackouts.​